Anaphylactic reactions of new Houttuynia Cordata injection
ZHANG Mei-yu
LI Lian-da
LI Yi-kui
ZHANG Jia
HAO Wei
Abstract：Objective: To evaluate the allergenicity of new Houttuynia Cordata injection ( NYI) in Beagle dogs. Methods; In anaphylactic and anaphylactoid reactions test, various doses of NYI were intravenously injected into Beagle dogs for sensitization, and double doses were injected 9 days after sensitization to challenge allergic reactions. The allergic reactions were observed, and the concentrations of histamine and IgE in plasma were measured with ELISA. Results; Beagle dogs did not show any abnormal behaviors after intravenous administration of NYI. Histamine and IgE were not obviously increased in anaphylactoid and allergic tests. Conclusion; NYI does not induce allergic reactions in Beagle dogs, providing a safety basis for the clinical medication.
Keywords：new Houttuynia Cordata injectionanaphylactic and anaphylactoid reactions testBeagle dogshistamineIgE
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)