Comparison of the efficacy and safety of thrombolytic therapy using low dose reteplase and alteplase in patients over 75 years with acute myocardial infarction
ZHANG Shuang-yue
WANG Xue-qing
LIU Chang-tao
BIAN Qiu-wu
MENG Xiao-jing
LIU Xiao-yuan
Abstract：Objective: To explore efficacy and safety of intravenous thrombolytic therapy using low dose reteplase and alteplase in patients over 75 years with acute myocardial infarction ( AMI). Methods; Fifty-four patients over 75-year-old with AMI were enrolled from 2006 to 2009. Patients were randomly assigned to receive low doses of either reteplase or alteplase therapy. Reteplase was administrated as 2 intravenous injections of 5 Mu at a 30-min interval. The rates of coronary artery recanalization at 1 h and 2 h were compared in 2 groups. The incidence of major adverse cardiac events ( MACE) within 30 days and the bleeding relevant complications were compared in 2 groups as well. Results: The recanalization rate of 1 h was higher in reteplase group than in alteplase group (62.1% vs 36.0% , P <0. 05). There was no difference in 2 h recanalization rate between 2 groups. No significant difference in MACE rate and bleeding complications was documented between 2 groups. Conclusion: Low dose reteplase is effective and safe in the treatment of elder patients over 75 years with AMI. It has superiority in coronary recanalization time in comparison with alteplase.
Keywords：myocardial infarctiontissue plasminogen activatorthrombolytic therapy
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)