Rationality of combination and proportion of cefotaxime/sulbactam in vitro
LI Chang-qing
CHEN Wei
WANG Ting
Abstract：Resistance to cefotaxime of clinically isolated Cram-negative bacterial strains is extremely serious, and production of β-lactamases is one of the main mechanisms. Cram-negative bacterial strains mainly express TEM, CTX-M, and SHV type p-lactamases hydrolyzing cefotaxime. These p-lactamases can be effectively inhibited by sulbactam. The inhibition of cefotaxime/sulbactam (1:1,2=1 ) is stronger than cefotaxime/sulbactam (4:1, 8:1). The antibacterial activity of cefotaxime/sulbactam ( 1:1 ～8:1) increased obviously in the antimicrobial tests in vitro in three regions (Beijing, Sichuan and Xi'an) , and the effect of cefotaxime/sulbactam (1:1, 2: 1) was more suitable. The results showed that the cefotaxime/sulbactam combination is highly effective against cefotaxime-resistant Cram-negative bacterial strains, and cefotaxime/sulbactam (2:1) is the reasonable proportion.
Keywords：cefotaximesulbactambeta-lactamaseMICrelative hydrolysis rate
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)