Pharmacokinetic profile of freeze-dried cyclosporine A-Eudragit S100 nanoparticle formulation in dogs
FANG Zhi-gang
WANG Kai-peng
CHEN Ya-gen
ZHANG Jian-kang
WEI Miao
ZHANG Xue-nong
Abstract：Objecfive:To study the pharmaceutical characteristics of freeze-dried cyclosporine A-Eudragit S100 nanoparticles(CyA-S100-NP)in dogs.Methods:A random and two-way crossover study was adopted in 6 dogs.The blood concentration was determined by internal standard HPLC method after oral administration of CyAS100-NP and Neoral.Pharmacokinetics parameters were calculated using 3P97 program.Results:The concentration-time data were fitted as a two-compartment open model.The AUC of CyA-S100-NP was higher than that of Neoral(P＜0.05),while the CL significantly decreased(P＜0.05).The relative bioavailability of CyA-S100-NP was 135.9%as compared with Neoral.Conclusion:The bioavailability of CyA in CyA-S100-NP is significantly improved.CyA-S100-NP has the potential to develop a new CyA nanoparticle solid formulation.
Keywords：cyclosporine ApH-sensitive nanoparticlepharmacokineticsbioavailability
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)