Pharmacokinetics of gastrodigenin in rat plasma and CSF after intranasal and intravenous administration
WANG Qiao
CHEN Guo-shen
Abstract：Objective:To investigate the pharmacokinetics of gastrodigenin(p-hydroxybenzyl alcohol,HBA)in rat plasma and cerebrospinal fluid(CSF)after intravenous(i.v.)and intranasal(i.n.)administration.Methods:HBA was administered via I.v.at a dose of 50 or 10 mg·kg~(-1) and via i.n.at 10 mg·kg~(-1).Blood and CSF were collected at timed intervals for the measurement of HBA concentrations by high performance liquid chromatography.The calculations of pharmacokinetic parameters were performed by non-compartmental analysis using the software DAS 2.0.Results:HBA rapidly entered CSF after administration.AUC_(CSF) was higher than AUC_(plasma).There was no significant difference in AUC_(CSF) or AUC_(plasma) between I.n.and I.V.administrations.Conclusion:HBA can be absorbed into the systemic circulation rapidly and completely after intranasal administration.Intranasal HBA may be a promising alternative to intravenous administration.No extra direct nose-CSF transport could be demonstrated.
Keywords：gastrodigeninp-hydroxybenzyl alcoholpharmacokineticsintranasalintravenouscerebrospinal fluidplasma
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)