Effect of the traditional Chinese medicine Heshouwuyin on ovary morphology in aging rats
ZHANG Na
LI Ya-li
ZHANG Yao-heng
GAO Fu-lu
Abstract：Objective:To observe the ovary morphological changes in aging rats after treatment with the traditional Chinese medicine Heshouwuyin(HSWY).Methods:Rats(n=48)were randomly divided into 3 groups:normal,aging control and HSWY groups.Subacute aging model was induced by intraperioneal injection of D-galactose.The rats in HSWY group were administered with various doses of intragastric HSWY during D-galactose injection.The ovary morphology was observed by hematoxylin-eosin staining and transmission electron microscopy.Results:HSWY significantly increased the number of primordial follicles,growing follicles and corpus luteums(P＜0.05 or P＜0.01).HSWY improved the substructures of the granular cells,and increased the smooth endoplasmic reticulum,mitochondria and Golgi complex.Conclusion:HSWY can regulate the morphology of the ovary and prevent the apoptosis of granular cells,suggesting an anti-aging ability in rat sexual gland.
Keywords：Heshouwuyin(HSWY)agingratovarymorphologytransmission electron microscope (TEM)
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)