Effects of resuscitation with hypertonic saline and pentoxifylline on hemorrhagic shock-induced acute lung injury in rats
LIU Yu
TANG Ji-chun
TAN Da-hai
CHEN Zheng
ZHANG Yan
ZENG Yin-ming
Abstract：Objective:To determine the effects of resuscitation with hypertonic saline and pentoxifylline (HSPTX)on hemorrhagic shock-induced acute lung injury in rats.Methods:Twenty-four male Sprague-Dawley rats were randomly divided into 3 groups(n=8 in each group):sham,Ringer's lactate(RL)-and HSPTX-resuscitated groups.Rats were sacrificed in the end of the experiment,the lung water,neutrophil percentage and TP concentration in BALF.the Ievels of MPO,MDA and SOD in lung tissue were determined.The plasma levels of interleukinl β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by ELISA method.Results:All the lung water:neutrophil percentage and TP concentration in BALF;MDA and MPO in the lung tissue;and plasma levels of TNF-α and IL-1β significantly increased in RL and HSPTX groups as compared with sham group(P＜0.01).Lung water;neutrophil percentage and TP concentration in BALF;MDA and MPO in the lung tissue;and plasma levels of TNF-α and IL-1β were markedly lower in HSPTX group than in RL group.The levels of SOD in the lung were significantly higher in HSPTX group than in RL group.Conclusion:Resuscitation with HSPTX can decrease hemorrhagic shock-induced acute lung injury.
Keywords：pentoxifyllinelung injurymyeloperoxidasesuperoxide dismutasemalondialdehyde
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)