Preparation of cinnarizine floating sustained-release tablets
Abstract：Objective:To prepare and characterize the cinnarizine floating sustained-release tablets. Meth-ods:Solid dispersions were prepared with microcrystalline cellulose and citric acid as the carrier. The impact of the types of HPMC,dosage,and the film pressure,film track and other factors on drug release rate was measured using single-factor approach,and then the optimal prescription was obtained with the orthogonal design. Results: The floating sustained-release cinnarizine tablets were obtained successfully. The preparing method of solid dispersion improved cinnarizine dissolved preparation. The optimized prescription consisted of cinnarizine, citrate,microcrys-talline cellulose mass with the ratio of 1:1:3. HPMC K4M was selected as the skeleton material. The concentra-tions of HPMC, PEG 6000, octadecanol and adhesive,the pressure and tablet diameter were measured. Conclusion: HPMC type,dosage,PEG 6000 and octadecanol usage have a more significant impact on the rate of drug release than other factors.
Keywords：floating sustained-release tabletcinnarizinehydroxypropyl methyl cellulose
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)