Microwave synthesis and antitumor activity of curcumin analogs
Abstract：Objective: To synthesize four curcumin analogs and evaluate their antitumor activities. Meth-ods: Four curcumin analogs were synthesized by coupling the appropriate aromatic aldehyde and cyclohexanon with HCI catalysis under microwave irradiations. The antitumor activities of these analogs were evaluated by trypan blue staining assay. Results: Four curcumin analogs with structural unit of diene-ketone were synthesized and their structures were determined. They showed inhibitory effects in K562 cells in vitro. Conclusion: Four curcumin ana-logs are synthesized and have antitumor activities.
Keywords：curcuminmicrowave synthesisantitumor activity
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)