Inhibiting effect of silver nanoparticles on influenza virus H1N1
Abstract：Objective: To explore the inhibiting effect of silver nanoparticles (nanosilver, Nano-Ag) on in-fluenza virus H1N1. Methods: By hemagglutination test, chicken embryos cultivation and cytopathic effect (CPE), the effect of Nano-Ag on influenza virus H1N1 was detected. Results: The hemagglutination titer was 1:4 in Nano-Ag/H1N1 group and 1: 1 024 in the control group of influenza viruses H1N1(P<0.001). Nano-Ag effec-tively inhibited influenza virus H1N1 proliferation in of chicken embryos, and the hemagglutination was negative in allantoic fluids of Nano-Ag/H1N1 group. However, the hemagglutination titer was 1:1 024(P<0.001) in the control group. Nano-Ag 25 μg·mL~(-1)inhibited cytopathic effect and cell apoptosis induced by the influenza virus H1N1; apoptosis rate reduced from (22.0±2.4)% in the control group to (7.3±4.0)% in Nano-Ag/H1N1 group(P<0.001). Conclusion: Silver nanoparticles display obvious inhibiting effect on influenza virus H1N1.
Keywords：silver nanoparticlesinfluenza virus H1N1inhibitionapoptosis
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)