Progress in therapeutic targets and intervention of congestive heart failure
WANG Wei-ting
ZHAO Zhuan-you
TANG Li-da
Abstract：With the understanding of pathophysiological process in pathogenesy, process, and deterioration of congestive heart failure, novel targets for intervention is becoming the hope of the treatment for heart failure. In this paper, we summarized the therapeutic targets and intervention in process of cardiac hypertrophy including calcineurin(CaN), G protein, glycogen synthase kinase-3 (GSK3), myocyte enhancer factor-2 (MEF2), peroxisome proliferator-activated receptor(PPAR), small G proteins (sGp), Na~+/H~+ exchanger (NHE), subcellular organelles, as well as targets of apoptosis, endothelin (ET) and its receptors, inflammatory factors, and anemia. The purpose is to give references in R&D of new drugs on heart failure.
Keywords：congestive heart failuretargetmyocardial hypertrophyapoptosisendothelininflammatory factoranemia
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 486-493 )