Serious adverse drug reactions in children: an analysis from spontaneous reporting data in China during 2006
WANG Yu-xin
WANG Chun-ting
YANG Yue-ming
DU Xiao-xi
JIN Dan
Abstract：Objective:To indentify the general conditions and the risk factors of serious pediatric drugs adverse reaction(ADR) from the reports of National spontaneous reporting database during 2006.Methods:Totally,1088 pediatric serious ADR reports were collected by National Center for ADR Monitoring during 2006,and analyzed using retrospective study method.Results:Of 8128 overall serious ADR reports,1088 were pediatric ADR reports(13.40%).Most pediatric ADRs were induced by antimicrobial drugs,traditional Chinese medicines and biologic products,and the most frequently affected organ system was systemic disorder relating to anaphylactoid reactions.Of the serious pediatric ADR reports,101 deaths occurred.Lots of deaths were associated with antimierobial drugs and biologic products,and the causes of death were mostly anaphylactic shock.Conclusion:Pediatric drug therapy and the features of the pediatric immune systems and pharmacokinetics lead to serious pediatric ADRs.
Keywords：pediatricADR reportanalysis
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 453-456,448 )