Preparation of dipyridamole microemulsion and its quality evaluation
HE Bo-sai
NIE Shu-fang
YAN Ting-xu
LIU Qiang
PAN Wei-san
Abstract：Objective:To prepare the O/W microemulsion of dipyridamole and study its stability and quality.Methods:The primary compositions of microemulsion were obtained through the solubility of dipyridamole in various solvents.The formulation was optimized in pseudo-ternary phase diagrams and the physicochemical properties,including viscosity,conductivity,refractive index,zeta potential,particle size distribution and stability,were examined respectively.Results:The maximum area of microemulsion in pseudo-ternary phase diagrams was obtained when Km was 3:1.The mean droplet size of microemulsion was 59.7 nm.The microemulsion was stable under high speed centrifuge,high temperature and strong light condition.Conclusion:The solubility of optimized microemulsion was improved significantly.The microemulsion was easy to prepare and had a good stability.The determination method was reliable and easily repeated.
Keywords：dipyridamolemicroemulsionpseudo-ternary phase diagramssolubilityquality evaluation
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 444-448 )