Studies on the quality control method of Zhibai Dihuang effervescent granules
TU Wan-qian
ZHANG Liu-ji
LIU Yi
YAO Chun-min
Abstract：Objective:To establish the quality control standard for Zhibai Dihuang effervescent granules.Methods:Cortex Moutan,Fructus Corni,Cortex Phellodendri Chinensis were identified by TLC.The contents of loganin and paeonol were determined by HPLC.A Hypersil C_(18) column(250 mm ×4.6 mm,5 μm) was used.The mobile phase for loganin was acetonitrile-water(14:86) at the flow rate of 1.0 mL· min~(-1),and the detection wavelength was 240 nm.The mobile phase for paeonol was methanol-0.1% H_3PO_4(47:53) at the flow rate of 1.0 mL·min~(-1),and the detection wavelength was 274 nm.Results:The identification of Cortex Moutan,Fructus Corni and Cortex Phellodendri Chinensis was highly specific without interference.The average recovery rates of loganin and paeonol were 99.14%(RSD=0.87%) and 101.21%(RSD = 2.00%),respectively.The linear range of loganin and paeonol were 0.181 2～1.359 0μg(r = 0.999 9) and 0.099 ～0.495 μg(r = 0.999 6),respectively.Conclusion:The method is accurate and reliable to control the quality of Zhibai Dihuang effervescent granules.
Keywords：Zhibai Dihuang effervescent granulesquality controlloganinpaeonolcontent determination
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 439-443 )