Study on solid lipid nanoparticles as transdermal administration carrier for tretinoin
CHEN Zheng-ming
LONG Xiao-ying
DING Mu-gan
DING Gang
LU Xiu-xia
SHAO Hong-xia
Abstract：Objective:To improve the stability of tretinoin and increase the local concentration of drug when transdermal administration through solid lipid nanoparticles(SLN) as carrier for tretinoin.Methods:Tretinoin SLN was prepared by nano-emulsion method.The formulation was determined through phase diagram and optimized by single factor experiments.The entrapment efficiency was determined by Sephadex G50 mini-column.Preliminary evaluation of tretinoin SLN was carried out including stability,in vitro release,skin penetration and retention.Resuits:The shape of SLN was spherical or similar,the mean particle size was 83.2 nm,entrapment efficiency was over 95%.Both drug content and entrapment efficiency of SLN had no significant change after being storaged at 4 ℃,25 ℃ and 40 ℃ in a light-resistant container for 3 months.SLN showed slower release rate and skin penetration in vitro than cream in market,but stronger skin retention.Conclusion:SLN as transdermal delivery carrier for tretinoin could improve its stability and increasing local concentration of drug.
Keywords：tretinoinsolid lipid nanoparticles(SLN)stabilityin vitro releaseskin penetrationskin retention
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 427-434 )