Effect of Y-IP5 on morphine-induced analgesia tolerance and physical dependence in mice
XU Yue-fang
SU Rui-bin
YANG Ri-fang
WU Ning
LU Xin-qiang
LI Jin
Abstract：Objective:To analyze the effect of Y-IP5 on morphine-induced analgesia tolerance and physical dependence in mice.Methods:Effect of Y-IP5 on morphine-induced analgesia and tolerance was evaluated by 55 ℃ hot plate test.Morphine was sc injected for 5 clays in an escalating dose schedule to induce physical dependence.The effect of Y-IP5 on physical dependence in morphine-dependent mice was observed.Results:In 55 ℃ hot plate test,Y-IP5(2.5,5,10 rag·kg~(-1)) did not enhance morphine analgesia(P>0.05),but it(1.25,2.5,5 mg·kg~(-1)) significantly inhibited morphine-induced tolerance(P<0.05).Concomitant Y-IP5(1.25,2.5,5 mg·kg~(-1)) injection with morphine dose-dependently inhibited the development of morphine-induced physical dependence(P<0.05).However,Y-IP5(1.25,2.5,5 rag·kg~(-1)) did not inhibit the expression of morphine-induced physical dependence when it was given before naloxone injection(P>0.05).Conclusion:Y-IP5 has a significant inhibitory effect on the development of morphine-induced tolerance and physical dependence in mice.
Keywords：Y-IP5N-methyl-D-aspartate(NMDA)analgesiatolerancephysical dependence
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 412-416 )