Clinical efficacy and safety of domestic vancomycin hydrochloride in the treatment of gram positive coccal infections
FAN Hong-wei
LI Hua-yin
JIAO Li
XU Ying
CAO Bin
HUANG Shao-guang
HE Li-xian
ZHANG Jie
TIAN Ding
CHEN Hui-de
WANG Ai-xia
Abstract：Objective:To compare the safety and efficacy of domestic vancomycin hydrochloride(Laikexin~(R)) and import vancomyein hydrochloride(Vancocin~(R)) in the treatment of resistant gram-positive coccal infections.Methods:In a multiple center,randomized,controlled and opened clinical trial,61 patients were enrolled.Of them 31 patients were treated with Laikexin~(R),and 30 patients were treated with Vancocin~(R) at doses of 1.5～2 g Chinese Journal of New Drugs 2010,19(5)
per day intravenously for 7～14 days.Results:The clinical response rate and bacterial clearance rate were 83.3%
and 50% in Laikeixn~(R) group,and 72.4% and 66.7% in Vancocin~(R) group,respectively.The adverse reaction
rates were 25.8% and 13.3% in two groups,respectively.The response rates and adverse reaction rates had no
significant difference between two groups.Conclusion:In the treatment of resistant gram-positive eoeeal infections,
the efficacy and safety of Laikexin~(R) are equal to Vancocin~(R).
Keywords：vancomycingram-positive coccusefficacysafety
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 391-395 )