Progress in the research of structure-activity relationship of the benzamide class of histone deacetylase inhibitors
JIAO Jie
HU Jian-qiang
FANG Hao
Abstract：Histone deacetylase(HDAC),a class of zinc-dependent metalloprotease existing in all kinds of eukaryotic cells,has important biological function.HDAC inhibitors(HDACi) have emerged as a novel class of noncytotoxic antitumor agents.They are attracting attention of the researchers in the world because they can exhibit exciting inhibitory activity to selectively inhibit proliferation,maturation,migration and diffusion of various solid tumor,lymphoma and leukaemia cells.Most of HDACi exert their enzymatic inhibitory activity by chelating the zinc ion in the catalytic,site of HDAC.The benzamide class of HDACi,characterized by the N-(2-aminophenyl)benzamide,is an active pharmacophore that ensure the potent oral bioactivity and antitumor activity.This review mainly summarizes structure-activity relationship of this class of HDACi in recent years.
Keywords：histone deacetylaseinhibitornoncytotoxic antitumor agentsN-(2-aminophenyl) benzamidestructure-activity relationship
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 386-390 )