Preparation of baicalein self-microemulsifying drug delivery systems and oral bioavailability in rat
KE Xue
YAN Fei
HU Yi-qiao
Abstract：Objective:To prepare baicalein self-microemulsifying drug delivery systems(SMEDDS) and study its oral bioavailability in rat.Methods:The pseudo-ternary phase diagrams were constructed to evaluate the effect of different oils,surfactants and cosurfactants.The baicalein concentration in rat plasma was determined by a HPLC method.,The oral bioavailability of SMEDDS in rats was studied compared with the pure baicalein.Results:A good SMEDDS of baicalein was obtained by using composite oils,composite surfactants and cosurfacant.Compared with pure baicalein,the relative bioavailability of SMEDDS was 377%.The curve of plasma concentration versus time was changed.Conclusion:The SMEDDS resulted in a significant increase of the solubility of baicalein,which is advantageous for the oral bioavailability.The absorption behavior of baicalein from intestine may be modified by SMEDDS.
Keywords：baicalein(BA)self-microemulsifying drug delivery systems(SMEDDS)bioavailability
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 371-376,395 )