Improved synthesis of hypolipidemic drug bezafibrate
WU Jie
GU Xu
LI Dong
DING Ai-zhong
DAI Xiao-yang
Abstract：Objective:To improve the synthesis process of hypolipidemic drug bezafibrate. Methods:Start-ing from 4-chlorobenzoyl chloride and tyramine, N-(4-chlorobenzoyl)-tyramine was obtained, and then condensed with acetone and chloroform in presence of PTC in toluene to synthesis bezafibrate. Results:The structure of bezaf-ibrate was confirmed by ~1H-NMR. The overall yield of condensation reaction was up to 73%. Conclusion:The im-proved synthetic process with higher yield and simplified operation, free from the anhydrous condition. The solvent can be isolated via extraction. Thus it is applicable to manufacture.
Keywords：bezafibratesynthesislipid-lowering drug
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：2( 311-312 )