Progress in research and application of polymer-drug conjugates
KONG Yan
LIAO Yong-xiang
HU Nai-feng
WANG Pu
Abstract：Polymer-drug conjugates (PDCs) can be synthesized using drug modification polymers (DMP). PDCs have big molecular weights, functional groups and drugs used in clinic, and are formed by chemical bonds at a definitive position. Various types of drugs, including proteins, oligonucleotides and chemical anticancers, can be used to make PDCs. Since the participation and intervention of the DMP, the produced PDCs have stronger anti-enzymolysising ability, better stability and longer half-life of metabolism, better permeability across cell membrane, increased concentration in cancer cells, smooth releasing, and lower toxic and side effects as compared with the original drugs in the human body. The research and development of the PDCs is an important direction in the new and efficient drug development fields.
Keywords：polymer-drug conjugatesdrug modification polymerfunctional grouplinking at a definitive position
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 290-295 )