Synthesis of intermediate of hydrocortisone of pregn-4-ene-17α,21-dihydroxy-3,20-dione-21 -acetate
HE Ming-hua
LIAO Qing-jiang
Abstract：Objective: To synthesize the intermediate of hydrocortisone. Methods:Androstendione (AD) was primer. The intermediate of hydrocortisone, pregn-4-ene-17α,21- dihydroxy-3,20-dione-21-acetate was synthesized using the etherification protection, Wittig reaction, the KMnO_4 oxidation, Py·SO_3 oxidation synthesis. Results:C_(17)-side chain was induced into group. Conclusion: The synthesis route has less synthetic steps and a mild condition. It was suitable for industral production.
Keywords：androstendione(AD)the intermediate of hydrocortisonepregn-4-ene-17α21- dihydroxy-320-dione-21-acetatesynthesis
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 233-235 )