Preparation of lidocaine silk double-deck membrane and its biocompatibility
WU Li
ZHOU Xin-ying
ZHANG Xue-nong
Abstract：Objective: To prepare a silk compound membrane of lidocaine hydrochloride and study its in vitro release characteristics and biocompatibility. Methods:The silk compound membrane was prepared with glycer-ine as elasticizer. The prescriptions of formulation and preparation process were screened by the uniform design for permeation rate. The release characteristics of silk compound membrane was studied and compared with the mono-layer one. The biocompatibility of silk compound membrane of lidocaine was investigated. Results: The release mechanism of silk compound membrane of lidocaine in vitro was coincided with Higuchi Equation, and the release characteristics of compound membrane was better than the monolayer one. The transdermal absorption reached peak when the ratio of azone to propylene glycol was 1.6% : 2.0%. The biocompatibility is good. Conclusion : Silk com-pound membrane is effective as vehicle for transdermal therapeutic drugs, also has a satisfactory prospect.
Keywords：silk compound membraneuniform designin vitro releasepercutaneous absorptionbiocom-patibility
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 161-167 )