Preventive and therapeutic effects of rhBMP-7 on chronic renal failure induced by adenine in rats
CHI Ming-feng
HAN Jin-xiang
WANG Shi-li
ZHENG Xiu-feng
YUAN Guang-ying
Abstract：Objective: To observe the preventive and therapeutic effects of recombinant human bone mor-phogenetic protein-7 (rhBMP-7) on chronic renal failure induced by adenine in rats. Methods: Chronic renal fail-ure was induced by intragastric adenine(300 mg·kg~(-1)·d~(-1)) for 35 days in Wistar rats. For the preventive effects, rhBMP-7(300 μg·kg~(-1)) was ip injected every other day during adenine treatment. At 35 days after treatment, re-nal function, biochemical indicators, kidney index and renal pathologic changes were determined. For the thera-peutic effects, rhBMP-7(100 and 300 μg·kg~(-1)) was ip injected every other day from 36 days of adenine treatment to 70 days. On 70th day, the same indicators were observed. Results: rhBMP-7 declined the levels of BUN, Cr, UA and P~3, and increased the level of Ca~(2+) somewhat; it also improved anemia, reduced the renal index and at-tenuated the injury of kidney. Conclusion: rhBMP-7 improves the renal dysfunction in rats with chronic renal fail-ure induced by adenine.
Keywords：recombinant human bone morphogenetic protein-7chronic renal failureadenine
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 157-160,146 )