Preparation of osmotic pump controlled release tablet of salvianolic acid B
LIU Rui
LIU Zhi-dong
GAO Guo-yi
Abstract：Objective:To study the formulation and technology of salvianolic acid B osmotic pump con-trolled release tablets and investigate the influencing factors on drug release. Methods:The cumulative percent re-lease was used as the evaluation standard for the drug release profile in vitro. Single factor tests were carried out on the formulation to determine the optimal formulation. Results: The type and amount of osmotic promoting agents, the type and the amount of PEG, the weight of coating showed influence on the drug release behavior, while the hardness of tablet core, the diameter of orifice, the in vitro release condition had no significant effects. Conclusion: More than 92% of salvianolic acid B was released from the salvianolic acid B osmotic pump controlled release tablets in twelve hours in vitro (r = 0. 993 1), following zero-order charactors.
Keywords：salvianolic acid Bosmotic pumpcontrolled release tablet
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 142-146 )