Preparation of piperacillin sodium/tazobactam sodium (4: 1)for injection
LI Jian-he
LI Yin-bo
CAO Jun-hua
CUI Wei
WAN Xiao-min
PENG Liu-bao
Abstract：Objective: To prepare piperacillin sodium/tazobactam sodium(4: 1)for injection and to establish the corresponding quality control method. Methods: Piperacillin sodium/tazobactam sodium(4: 1)for injection was separately packed with the aseptic technology. The contents and the related substances were determined by the method of high performance liquid chromatograph(HPLC)and the stability and the safety were investigated. Resuits: The average recovery of piperacillin and tazobactam were 99.9%and 99.8%with RSD 0.5 1%and 0.40%,respectively.The preparation showed good stability under the experimental conditions of stress test, accelerated test and long. Term test. It showed good safety after blood vessel stimulation test, muscle stimulation test, haemolyticus test and system sensitivity test. Conclusion: The prescription and technology of the preparation are reasonable with controllable quality, satisfactory stability and good safety.
Keywords：piperacillin sodium/tazobactam sodium(4: 1)for injectionprescriptiontechnologyquality controlstabilitysafety
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 79-83 )