Synthesis of 4-deacetylVinblastine amino acid analogues
ZHANG Ai-hong
ZHONG Bo-hua
Abstract：Objective: To synthesize 4-deacetylvinblastine amino acid analogues, and to supply key synthetic methods for vinblastine prodrugs. Methods: Amino acids were protected by Z groups at N-terminal coupled with 4-deacetylvinblastine using the mixed anhydride method, and then deprotected by catalytic hydrogenation to obtain target compounds. Results: 4-Deacetylvinblastine amino acid analogues were successfully synthesized and conformed by ESI-MS and ~1H-NMR.Conclusion: The more applicable synthetic method can optimize the synthetic process and is suitable for synthesis of 4-deacetylvinblastine amino acid analogues.
Keywords：vinblastineN-terminal Z group protected amino acidmixed anhydride method
Publication Date：2010-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 64-67,71 )