Immunosuppressive effect of paclitaxel liposome on B lymphocytes
WANG Yong-fu
CHANG Zhi-fang
WANG Hui
LI Zhan-guo
Abstract：Objective: To investigate the inhibition effect of paclitaxel liposome on B lymphocytes. Methods:XG-7 cells were treated with paclitaxel liposome(1,2.5,5,10 and 20 ng·mL~(-1)) for 24h.The prolif-eration of XG-7 cells was detected by cell counting kit 8 (CCK8) . The levels of IgG and BAFF in cell supernatants were measured by enzyme-linked immunosorbent assay (ELISA). Results: Paclitaxel liposome inhibited the prolifer-ation of XG-7 cells in a concentration-dependent manner,and the proliferating activity was gradually decreased with increasing of the concentration. The levels of IgG and BAFF in supernatants were gradually reduced with increasing of the concentration. Conclusion: Paclitaxel liposome induces B lymphocyte apoptosis, which may provide a new method for finding new medicines to treat autoimmune disease.
Keywords：paclitaxel liposomeimmunosuppressionB lymphocyte
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2345-2348 )