Efficacy and safety of Shuangdan Mingmu capsule in treating diabetic retinopathy

TU Liang-yu; WANG Wen-chang; WANG Yu-liang; ZHANG Ming-liang; HUANG Wei-ping

doi:10.3321/j.issn:1003-3734.2009.24.013

Abstract：Objective: To investigate the efficacy and safe of Shuangdan Mingmu capsule in treating simple diabetic retinopathy. Methods: The diagnostic criteria of diabetic retinopathy were based on Diagnostics of Ophthal-mology and Practical Ophthalmology(published by Peoples Medical Publishing House). A total of 202 patients with diabetic retinopathy were randomly divided into two groups. They were treated with Shuangdan Mingmu capsule for 16 weeks ( n = 102) ,or with Daoshengming for 16 weeks ( n = 100). All the patients were inspected before treat-ment, and 8 and 16 weeks after treatment. The items of inspection were acuity of vision, campus visualis, fluores-cence fundus angiography, and other clinical symptoms and signs of diabetic retinopathy. Results: The numbers of retina microaneurysm, haemorrhage, effusion, leakage, and the areas of capillary nonperfusion and defect of field vi-sion were significantly decreased and the acuity of vision was significantly increased 16 weeks after treatment in both groups. The scores of ophthalmology inspection and scores of microaneurysm at 8 and 16 weeks after treatment were significantly better in Shuangdan Mingmu Capsule group than in Daoshengming group (P<0.01 or P <0.05). The score of visual activity test 16 weeks after treatment was significantly better in Shuangdan Mingmu capsule group than in Daoshengming group ( P <0. 01 or P <0. 05 ) . The markedly effective rate and total effective rate of disease were significantly better in Shuangdan Mingmu capsule group (P <0.05). The rate of adverse reactions was less in Shuangdan Mingmu capsule group than in Daoshengming group. Conclusion: Shuangdan Mingmu capsule is safe and effective in patients with simple diabetic retinopathy, and is better than Daoshengming in decrease of numbers of retina microaneurysm, increase of acuity of vision and improvement of dryness of eyes.