Pharmacology and clinical evaluation of eltrombopag
ZHU Yi
FU De-xing
Abstract：Idiopathic thrombocytopenic purpura(ITP)is an autoimmune disease, in which platelets were destructed due to the effects of antiplatelet antibodies, and severe blooding could be caused.Corticosteroids,immu-nosuppressants,anti.CD20 antibody and splenectomy have been used for the conventional therapy of ITP. But re-lapse and side effects occurred frequently. Eltrombopag is a nonpeptide small molecule for oral use, and have been proven to act on the receptors of thrombopoietin (a thrombopoiesis regulating cytokine)and could lead to megakaryocyte differentiation and platelet production. The mechanism, pharmacodynamics, pharmacokinetics and clinical therapeutics of eltrombopag were reviewed in this paper.
Keywords：eltrombopagidiopathic thrombocytopenic purpurapharmacologyclinical evaluation
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 2291-2293 )