Pharmacokinetics and tissue distribution of stealth etoposide liposomes in rats
LI Jin-ming
CHE Huan-yu
LI Xin
ZHANG Yan-zhuo
LI Bo
Abstract：Objective:To study pharmacokinetics and tissue distribution of stealth etoposide liposomes in rats. Methods: The drug concentration of etoposide in rat blood circulating system and various tissues were deter-mined by high-performance liquid chromatograph (HPLC). Results: Following intravenous injection administration at the dose of 4 mg · kg~(-1) etoposide, the two-compartment model discribed the two kinds of etoposide preparations.The main pharmacokinetic parameters of stealth liposomes were as follows:T_(1/2)α (2.26 ±0.25)h,T_(1/2)β (17.44 ±2.07)h,and AUC (56. 13 ±8.21) μg·mL~(-1) · h,respectively. The main pharmacokinetic parameters of injection were T_(1/2)α(0.08 ±0.02)h,T_(1/2)β (1.24 ±0. 19)h,and AUC (2. 16 ±0.50) μg·mL~(-1) ·h,respectively. In tissue distribution, the concentration of etoposide in the lung was the highest and those in the liver, spleen, heart and kid-ney was lower sequentially at 15min after intravenous injection stealth liposomes, then drug concentration descended slowly compared with injections and remained at low level from 2 h to 12 h. Conclusion: Stealth Etoposide lipo-somes for intravenous injection could extend the duration of etoposide in blood and tissue.
Keywords：etoposideHPLCtissue distributionpharmacokinetics
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2269-2272,2277 )