Diphasic function of xylitol in osmotic pump preparations as a novel excipient
ZHANG Zhi-hong
SUN Guang-mei
YANG Xing-gang
PENG Bo
LI Ning
PAN Wei-san
Abstract：Objective:To discuss the feasibility of the application of xylitol in osmotic pump preparation.Methods;The stability and the interference of xylitol on the determination of target compound were tested. Elemen-tary osmotic pump(EOP) and push-pull osmotic pump( PPOP) were prepared using xylitol as a penetrating agent and a channel agent. The dissolution behavior of xylitol was compared with the osmotic pump tablets using NaCl as a penetrating agent and PEG as a channel agent. Results: Xylitol was stable except in strong acidic and oxygenic surrounds,which just had a weak UV absorption in short wavelength,thus it did not disturb the measurement of drugs. The penetrating ability of xylitol was as good as NaCl. The ability of xylitol as a channel agent was the same as PEG with an appropriate switch of the amount. Conclusion: Xylitol could be used in osmotic pump preparations as a penetrating agent and a channel agent.
Keywords：xylitolosmotic pumppenetrating agentpore formermetformin HClglipizide
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2264-2268 )