Dissolution behavior in vitro and pharmacokinetic profile of albendazole solid dispersion in rats
HUANG Yi
YAN Ming
KANG Ai-rong
MAO Yan
ZHAO Jun
HE Jin-hua
WANG Huan
Abstract：Objective:To evaluate the albendazole ( ABZ) solid dispersion dissolution behavior of ABZ in vitro and pharmacokinetics of the rats. Methods: ABZ solid dispersion was carried out by solvent-evaporation method. The dissolution results were fitted by three functions,and the dissolution behavior of solid dispersion and other three samples was studied. The plasma concentrations were determined by HPLC and pharmacokinet-ic behaviors were evaluated in rats. Results: The dissolved amount from solid dispersion at 20min was much higher(92. 8% ) than that of the market tablet(76. 5% ) ,simple mixture(40. 8% ) and raw material. The ac-cumulative release percentage of all of them was described by Weibull function. The area under the curve (AUC)and C(max) were significantly higher in solid dispersion group than that in the market tablet. The calcula-tion results by both compartment model and statistical moment model were the same,and the relative bioavail-ability of solid dispersion was 230 percent. Conclusion: The solid dispersion system can improve ABZ dissolu-tion in vitro and absorption in vivo significantly.
Keywords：albendazolesolid dispersiondissolutionbioavailability
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 2259-2263,2249 )