Antitumor activity of 13-methyltetradecanoic acid
HUANG Mei
CHEN Xu-dong
HE Long-gang
Abstract：Objective:To investigate the antitumor effect of 13-methyltetradecanoic acid (13-MTD). Meth-ods: Both in vitro and in vivo tests for antitumor activity were conducted,and the effect of 13-MTD on immune func-tions was examined. Results:In in vitro test,the IC_(50) ranged from 13. 9 to 33. 0 μg·mL~(-1) for six tumor cell lines,in-cluding mammary adenocarcinoma Bcap-37 cells. In in vivo test,intragastric 13-MTD 400 mg·kg~(-1) per day inhibited tumor size by 71. 74% in solid tumor model of S_(180) ,and extended life-span by 41.49% in leukemia model of P_(388).13-MTD had no significant effect on immune function of normal mice. When combined with cyclophosphamide (CTX) , 13-MTD did not aggravate the immune suppression induced by CTX,but actually reversed such immune suppression in some indexes such as thymus index. Conclusion: In both in vitro and in vivo tests,oral 13-MTD has significant antitumor activity for growth of cancer cell lines and xenografted tumors in mice. This agent does not sup-press immune functions, nor aggravate the immune suppression induced by combination treatment with CTX.
Keywords：antineoplastic agents13-methyltetradecanoic acidtumor cellsneoplasm transplantationim-mune function
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2255-2258 )