Effect of Trichosanthes kirilowii Allium macrostemon injection on acute myocardial ischemia and hemodynamic parameters in dogs
GONG Shu-bo
LI Yun-man
FANG Wei-rong
L(U) Peng
GU Wei
SHEN Xiao-lan
Abstract：Objective:To study the effect of Trichosanthes kirilowii Allium macrostemon(TKAM) on acute myocardial ischemia induced by ligation of coronary artery, and on the hemodynamic parameters in anesthetized thoraco-opened dogs. Methods : Myocardial ischemia was developed by ligation of the left coronary anterior descend-ing artery in the anaesthetized thoraco-opened dogs. TKAM at 58.7, 29.3 and 14.7 mg·kg~(-1) was administrated.
The epicardial electrocardiogram and the quantitative histological analysis combined with nitroblue tetrazolium
(NBT) staining were used to determine the range and degree of the damage induced by myocardial ischemia. The activities of serum CK,LDH and MDA were determined. The effect of TKAM on hemodynamic parameters was ob-served by electromagnetic flowmetry. Results:TKAM significantly decreased the severity of myocardial ischemia and the extent of myocardial infarction. TKAM obviously reduced serum CK and LDH activities, and MDA content, and also improved the hemodynamic parameters. Conclusion: TKAM can protect anesthetized thoraco-opened dogs from myocardial ischemia induced by ligation of coronary artery; it can also improve the hemodynamic parameters.
Keywords：Trichosanthes kirilowii Allium macrostemon(TKAM)myocardial ischemiaepicardial elec-trocardiogramhemodynamic
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2155-2159 )