Therapeutic effect of nerve growth factor on acrylamide-intoxicated peripheral neuropathy in rats
LI Yan-kun
GAO Ming-tang
LI Wen-guang
WU Yong-jie
Abstract：Objective: To investigate the effect of nerve growth factor (NGF) on acrylamide-intoxicated peripheral neuropathy in rats. Methods: Peripheral neuropathy was induced by intragastric administration of acryl-amide. The intoxicated rats were intramuscularly injected with NGF (1 000, 2 000 and 4 000 BU·kg~(-1), respective-ly) daily for 8 days. Neurobehavioral responses (landing foot splay and gait scores) were measured during the course of treatment with NGF. Electrophysiological test ( nerve-muscle action potential and nerve conduction veloci-ty) and histopathological examinations were performed on the next day after the last dose of NGF. Results: Acryl-
amide significantly deteriorated neurobehavioral and electrophysiological responses, and caused an alteration of his-
tomorphology in tibial nerve fiber (such as myelin sheath swelling and axons degeneration). NGF (1 000, 2 000 or
4 000 BU·kg~(-1)) attenuated these injuries, and reversed axons degeneration. Conclusion: NGF may be a useful treatment agent for patients with acrylamide-intoxicated peripheral neuropathy.
Keywords：nerve growth factoracrylamideperipheral neuropathyaxons degeneration
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 2145-2150 )