Pharmacokinetics and bioequivalence of levonorgestrel tablet in healthy female volunteers
XU Ping-sheng
DAI Zhi-yong
QIN Qun
LEI Peng
XU Li-min
LI Xin-zhong
Abstract：Objective:To evaluate the bioequivalence of levonorgestrel tablet. Methods:According to the cross-over design, each volunteer was given a single oral dose of levonorgestrel tablet and then the plasma sample was obtained and determined by liquid chromatography-tandem mass spectrometry(LC-MS/MS) method. Results: The main pharmacokinetic parameters of single dose of the products were as follows: C_(max) ( 24.58±10.48) and (24.09±10.15)ng·mL~(-1), T_(max)(1.8±0.2)and(1.7±0.2)h,AUC_(0-72h)(241.9±99.8) and(244.9±105.8) ng ·h·mL~(-1) for reference and test respectively. The relative bioavailability was (102.6±24.8) %. Conclusion: The levonorgestrel tablets were bioequivalent.
Keywords：levonorgestrelLC-MS/MSpharmacokineticbioequivalence
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 2143-2144,2150 )