Preliminary evaluation of brain targeting via intranasal administration of galanthamine hydrobromide
HAN Xiao-lin
CHEN Xiao
YU Shan-jiang
YU Shao-yun
Abstract：Objective: To explore the feasibility of intranasal brain targeting drug delivery system via the olfactory pathway from nose to brain to treat Alzheimer disease (AD). Methods: Rats (n = 150) were randomly divided into three groups. The fate of drug in the plasma and brain was monitored after intragastric, intravenous and intranasal administration of 8 mg·kg~(-1) galanthamine hydrobromide. The concentrations of parent drug in plasma and brain were determined by HPLC with UV detection. The concentration-time data were analyzed using 3P87 pharma-cokinetic program. Results: The absorption of galanthamine hydrobromide by intranasal administration was fast. The AUC value of brain after intranasal administration was about 3. 2 and 2. 2 times of that after intragastric and intravenous administration, respectively. However, the AUC value in plasma obtained after intranasal administration was about 0. 54 and 0. 21 times of that after intragastric and intravenous administration, respectively. Conclusion: Intranasal administration of galanthamine hydrobromide significantly increases its concentrations into rat brain tissues, and enhances the brain targeting of the drug, which provide a potent therapeutic alternative in the treatment of AD.
Keywords：galanthamine hydrobromidebrain targeting via intranasal administrationpharmacokinetics
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 2084-2088 )