Evaluation for developmental toxicity of rhodioside injection in rats
ZHU Yu-ping
ZHU Jiang-bo
MA Xi-li
TIAN Yi-jun
WAN Xu-ying
ZHANG Tian-bao
Abstract：Objective: To evaluate the developmental toxicity of rhodioside injection in rats. Methods: In the present study, developmental toxicity in Sprague-Dawley rats was induced by intravenous injection of rhodioside (0, 0. 125, 0. 25 and 0. 5 g·kg~(-1)) daily on gestation day 6 ～ 15. Pregnant rats were sacrificed on 20th day of gestation. Reproductive indices were determined and fetuses were examined for external, visceral and skeletal malformations. Results: There were no significant differences between three treatment groups and control group in weigh gain, live fetus rate, dead fetus rate, absorbed fetus rate, external malformations rate, viscera malformations rate and skeletal malformations rate. In larger doses, abnormality of sternal vertebra, distal phalanges, distal metatarsal bone and sacral vertebra were found in some rats. In smaller doses (such as 0. 125 g·kg~(-1)) , growth and development of fetus were even promoted, I. E. the body length, placenta weight and fetus body weight were larger than that of control group. Conclusion: Rhodioside does not show conspicuous parent toxicity, teratogenic effect, em-bryotoxicity in SD rats are found at the dose levels of 0. 125 , 0. 25 and 0. 5 g·kg~(-1). The larger doses induce low-grade retardation of calcification effect on skeleton development and smaller doses promote growth and development of fetus somewhat.
Keywords：rhodioside injectionparent toxicityteratogenic effectembryotoxicityfetotoxicity
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 2068-2071 )