Preparation,characterization and biological evaluation of azido-seconucleoside analogues
RAN Xu
BAI Yong
CHEN Yao
JIANG Fa-qin
ZHANG Jian-cun
FU Lei
Abstract：Objective: To synthetize 2' , 3 '-azido-2 ' , 3 '-seconucleoside analogues, and to determine the potential antiviral activity. Methods: The target compounds were synthesized from natural nucleosides, through sulfo-nylation at 2 ' ,3 ' -OH and nucleophilic substitution by NaN_3. Results and Conclusion:The structures of these com-pounds were confirmed by ~1H NMR, ~(13)C NMR and HRMS analyses. All the target compounds showed moderate anti-HSV-I activity, which might contribute to the research on SAR of nucleosides analogues in this field.
Keywords：azidoseconucleosidespreparationcharacterizationevaluation
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1995-1998,2001 )