Effect of intravenous propofol on muscarinic or NMDA receptor in the brain of aged rats
LIU Xiu-fen
WU Xin-min
LIU Yu-he
ZUO Ping-ping
YANG Nan
Abstract：Objective:To investigate the transient and permanent effect of continuous intravenous infusion of propofol at different doses on muscarinic receptor (M-R) and N-methy-D-aspartsile receptor (NMDA-R) in the brain of aged rats. Methods:In 18-months-old male or female SD rats, anesthesia was induced by intravenous injec-tion of propofol (10 mg·kg~(-1) ) through tail vein, and maintained by small or large dose (25 or 45 mg·kg~(-1)·h~(-1) ) for different time length (2 h or 4 h). Rats were decapitated and the hippocampus was removed 1d (for transient effect) , or 6 d and 12 d (for permanent effect) after administration. The binding capacities of M-R with [ ~3H] -QNB and NMDA-R with [~3H]-MK-801 were measured by radiant ligand binding analysis. Results:In transient and permanent effect groups,the binding capacities of M-R with [~3H]-QNB and NMDA-R with [3H]-MK-801 were not significantly different as compared with corresponding control. Conclusion: Intravenous propofol has neither transi-ent nor permanent effect on the binding capacities of M-R with [ ~3H] -QNB and NMDA-R with [ ~3H] -MK-801 in the hippocampus of aged rats.
Keywords：propofolaged ratsreceptormuscarinicN-methy-D-aspartate (NMDA)
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1975-1978,1982 )