Multi-center clinical trial of Yifuning capsule in the treatment of vaginal bleeding patients after medical abortion
LIAN Feng-mei
ZHAO Rui-hua
JIANG Xian-hua
AI Li
WANG Yan
CHEN Rui-xue
JIANG Jian-nan
CAI Yu-hua
Abstract：Objective:To evaluate the efficacy and safety of Yifuning capsule in the treatment of vaginal bleeding patients after medical abortion. Methods: Patients who had vaginal bleeding after medical abortion with blood stasis syndrome ( n =420) were recruited in a randomized , double-blind , placebo-paralleled control, multi-center clinical trial. The patients were randomly divided into 2 groups,and received a 7-day (twice a day) treatment of Yifuning capsules or placebo from the moment of foetal sac outing. The efficacy was evaluated 7 days after treatment by the vaginal bleeding time,vaginal bleeding loss,syndrome,Hb,the first time menstrual after medical abortion and full-abortion rate. The safety was evaluated based on the incidences of adverse events and laboratory examination. Patients were followed up until the first time of menstrual onset after medical abortion. Results: In FAS, the mean vaginal bleeding time was 229. 10 h (9. 54 days) in Yifuning group,and 331. 39 h (13.81 days) in placebo group. In PPS,the mean vaginal bleeding time was 222. 18 h (9. 26 days) in Yifuning group,and 327. 32 h ( 13. 64 days) in placebo group. The differences between two groups were significant in the vaginal bleeding time,the vaginal bleeding loss and curative effect on syndrome. Conclusion: Yifuning capsule provides an effective and safe therapeutic option for vaginal bleeding after medical abortion in patients with blood stasis syndrome.
Keywords：medical abortionplacebotraditional Chinese medicine (TCM)Yifuning capsule
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1958-1962 )