Effect of remifentanil on neuropathological changes after transient forebrain ischemia in rats
FANG Shu-dong
XU Hui
JIANG Hong
ZHU Ye-sen
Abstract：Objective:To study the effect of remifentanil pretreatment on forebrain ischemia/reperfusion (I/R) injury in rats. Methods:Thirty-eight male Sprague-Dawlay rats were randomly divided into 5 groups: sham group). Transient forebrain ischemia was induced by 10 min of bilateral common carotid artery (CCA) occlusion in combination with hypotension. At 30 min before the occlusion, rats were pretreated with intravenous remifentanil 0,min before and 10 rain after ischemia. At 3 days after reperfusion, brains were fixed and paraffin sections were cut. The total of damaged neurons was counted in hippocampal CA1 and CA4, cortex, and striatum; the percentage of dead neurons was calculated. Results:Physiologic variables were similar in all the groups. Forebrain ischemia sig-nificantly increased the percentage of dead neurons in hippocampal CA1 at 3 days after reperfusion. Remifentanil at neuron damage was found in hippoeampal CA4 in each group. In the cortex, the number of damaged neurons was less in REM6 and REM20 groups than in ischemie control group. In the striatum, damaged neurons were increased in all the isehemic rats as compared to sham group, but there were no significant difference among rats with or with-out remifentanil treatment. Conclusion:Remifentanil has protective effect on neuron damage after brain I/R injury in rats.
Keywords：piperidinesreperfusion injurybrain isehemiarats
Publication Date：2009-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 1333-1337 )