Evaluation of the efficacy and safety of domestic valsartanin treatment of primary hypertension
ZHANG Yun
LI Yi-shi
GUO Ji-zhen
JIANG Shi-sen
XU Jun
JIANG Wen
WANG Li
GONG Pei
CHENG Xiao-ru
Hua Lu
Abstract：Objective:To evaluate the efficacy and tolerability of domestic valsartan in treatment of primary hypertension.Methods:After 1 week washing out and 2 weeks of placebo run-in period,124 patients with a seated diastolic BP (SeDBP) of 12.63～15.29 kPa were randomly divided to receive once daily 80 mg valsartan or once daily 10 mg lisinopril both for 8 weeks.Doses were doubled at weeks 4 for patients with SeDBP≥11.97 kPa.Results:At the end of 8 weeks,the total effective rate and decrease in SeSBP/SeDBP ratio for valsartan were 69% and (1.73±0.67)/(2.13±1.60) kPa respectively,for lisinopril were 72% and (1.86±0.67)/(2.39±1.33) kPa respectively.No significant difference between groups was observed(P>0.05).At the end of 8 weeks,ABPM of valsartan showed that T/P of DBP and SBP was 50.2% and 67% respectively.No cough occurred to valsartan group and 17.2% to lisinopril group.Conclusion:Domestic valsartan is very effective in treatment of primary hypertension in daily dose of 80～160 mg with good tolerability.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 363-365 )