Synthesis of faropenem
HAN Hong-na
CHEN Xiao-fang
JIN Jie
LIU Jun
Abstract：Objective:The synthetic process of faropenem,(5R,6S)-6-［1-(R)-hydroethyl］-2-［2-(R)-tetrahydrofuryl］-penem-3-carboxylic acid monosodium salt,has been studied by the authors.Methods:Azetidinone was used as the starting material and the target compound was prepared via seven steps of reaction.They included displacement,condensation,organometallic reaction,induced cyclization,and hydrolysis.Results:In the induced cyclization step,hydroquinone was added in an attempt to simplify the operation.For increased yield,TBAF was substituted by 0.1mol*L-1 HCl in the process of removal of t-butyldimethylsilyl group from the side chain of penem.Conclusion:This synthetic procedure is mild,convenient,simple and gives good yield to 35.2%.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 350-352 )