The anti-virus and hepatoprotective effect of bicyclol and its mechanism of action
LIU Geng-tao
Abstract：Bicyclol is a synthetic novel anti-hepatitis drug.It has remarkable hepatoprotective and certain anti-hepatitis virus actions.Oral administration of 50,100,200 mg*kg-1 bicyclol protected livers of mice from damage induced by CCl4,D-galactosamine,acetoaminophen and B.C.G.plus lipopolysacharides (LPS) expressed in decreases of ALT and AST as well as morphological damage of liver tissues.Addition of bicyclol to the cultivated 2.2.15 cell line inhibited secretion of HBeAg and HBsAg as well as HBV-DNA level.The results of mechanistic study on bicyclol indicated that bicyclol is not an inhibitor of transaminase,but a cell membrane protector through elinmination of free radicals.Moreover,bicyclol can protect hepatocyte nuclear DNA from damage and reduce the apoptosis induced by immuno-stimulating compound Con A.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 325-327 )