Randomized double blind controlled study of leflunomide intreatment of rheumatoid arthritis
SHUAI Zong-wen
LI Xiang-pei
XU Jian-hua
LI Xiao-mei
Abstract：Objective:To evaluate the safety and efficacy of leflunomide(LEF)in comparison with methotrexate(MTX)in treatment of rheumatoid arthritis (RA).Methods:160 patients with active RA were equally divided to receive 20 mg daily LEF or 15 mg weekly MTX for 24 weeks and their efficacy and adverse events were observed.Results:The effective rate and significantly effective rate for LEF group were 81.54% and 36.92% respectively and for MTX group were 75.81% and 35.48% respectively with no significant difference between groups.The incidence of adverse events for LEF and MTX groups were 15.39% and 26.47% respectively,also no significant difference.Conclusion:LEF is an effective agent for treatment of RA with better tolerability.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 292-294 )