Progress in development of tumor angiogenesis inhibitors
XIAO Dong
DING Jian
Abstract：Tumor angiogenesis inhibitor is a class of new drugs that can destroy or inhibit tumor neovascularization,and can effectively block the growth and metastasis of cancer.It may be divided into five categories according to their mechanisms of action:class 1,drugs that block basement membrane breakdown;class 2,drugs that directly inhibit the growth of endothelial cell;class 3,drugs that block the activation of angiogenesis factor;class 4,drug that inhibit endothelial-specific integrin/survival signaling;and class 5,drugs with non-specfic mechanism of action.The main aim of this paper is to introduce the latest development in angiogenesis inhibitors that are undergoing clinical trials.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：4( 248-251 )