The pharmacokinetics and relative bioavailability of r apid dissolving tablet of famotidine in mouth
Abstract：Objective:To study the pharmacokinetics and bioavai lability of rapid dissolving tablet of famotidine in mouth and famotidine market tablet in rabbits.Methods:Rapid dissolving tablets in mouth and m arket tablets of famotidine were single-dose orally given to rabbits.The blood levels of famotidine was determined by HPLC method.Results:The AUC ,Cmax and Tmax of rapid dissolving tablets in mouth of famotidine we re (2 687.63±461.65)(ng*h)/ml,(658.18±84.97)ng/ml and (1.29±0.23)h,and t he AUC,Cmax and Tmax of market tablet of famotidine were (1 4 77.65±484.28)(ng*h)/ml,(202.80±57.29) ng/ml and (2.85±0.54)h. Conclusion:There is significant difference (P<0.01) between the AUC of two products,and the bioavailability of rapid dissolving tablet of famot idine in mouth is 181.88%.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 198-200 )