The pharmacokinetics of atofluding in cancer patients
Abstract：Objective:To explore the pharmacokinetic characteristi cs of atofluding in cancer patients.Methods:18 cancer patients were ra ndomly and equally divided to receive orally atofluding 800,1 000 and 1 200mg re spectively,after administration of atofluding,the serum level of its metabolites ,5-FU and TFU,at different time was determined by HPLC.Data obtained were treat ed and its pharmacokinetic parameters were calculated.Results:In human body,atofluding was metabolized mainly to 3-ortho-methylbenzoyl-5-fluorouri cil,the latter's pharmacokinetics was fitted to one-compartment model.Very grea t individual difference in atofluding metabolism was observed among patients.Pha rmacokinetic parameters of atofluding didn't differ significantly with doses.Conclusion:Very great individual difference was observed among patients i n metabolism of atofluding,and therapeutic drug monitoring or individualization of dose may be necessary.
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Publication Date：2001-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：3( 196-198 )